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Roskamp Institute Articles Better Science. Real Discovery.

October 30, 2012

Event: Journal Club ” Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure.”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 9:13 am

We will be presenting the paper on Friday (11/02/2012) at 4:00 PM in Roskamp Institute. Title: Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure.

Hill MN, Kumar SA, Filipski SB, Iverson M, Stuhr KL, Keith JM, Cravatt BF, Hillard CJ, Chattarji S, McEwen BS Disruption of fatty acid amide hydrolase activity prevents the effects of chronic stress on anxiety and amygdalar microstructure. Mol Psychiatry. 2012 Jul 10. doi: 10.1038/mp.2012.90. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

September 18, 2012

Event: Journal Club ” Stress-induced altered cholinergic–glutamatergic interactions in the mouse hippocampus.”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 10:32 am

We will be presenting the paper on Friday (9/21/2012) at 4:00 PM in Roskamp Institute. Title:  Stress-induced altered cholinergic–glutamatergic interactions in the mouse hippocampus.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

Lev Pavlovsky, Yifat Bitan, Hadar Shalev, Yonatan Serlin, Alon Friedman, Stress-induced altered cholinergic–glutamatergic interactions in the mouse hippocampus, Brain Research, Volume 1472, 7 September 2012, Pages 99-106.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

September 11, 2012

Event: Journal Club ” Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth.”

Filed under: Uncategorized — Tags: — Gogce Crynen @ 10:56 am

We will be presenting the paper on Friday (9/14/2012) at 4:00 PM in Roskamp Institute. Title: Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth.

Song P, Pimplikar SW (2012) Knockdown of Amyloid Precursor Protein in Zebrafish Causes Defects in Motor Axon Outgrowth. PLoS ONE 7(4): e34209

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

August 29, 2012

Event: Journal Club ” Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System: A Cholinergic Agonist Prevents Gut Barrier Failure after Severe Burn Injury.”

Filed under: Uncategorized — Tags: — Gogce Crynen @ 9:48 am

We will be presenting the paper on Friday (8/31/2012) at 4:00 PM in Roskamp Institute. Title: Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System: A Cholinergic Agonist Prevents Gut Barrier Failure after Severe Burn Injury.

Costantini TW, Krzyzaniak M, Cheadle GA, Putnam JG, Hageny AM, Lopez N, Eliceiri BP, Bansal V, Coimbra R. Targeting α-7 Nicotinic Acetylcholine Receptor in the Enteric Nervous System: A Cholinergic Agonist Prevents Gut Barrier Failure after Severe Burn Injury. Am J Pathol. 2012 Aug;181(2):478-86.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

August 21, 2012

Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier.

Filed under: Uncategorized — Gogce Crynen @ 2:10 pm

July 30, 2012

Dr. Bachmeier and Dr. Paris recently published an article in Journal of Molecular Neuroscience titled “Stimulation of the retinoid X receptor facilitates beta-amyloid clearance across the blood-brain barrier”. This report identified a role for RXR stimulation in the clearance of Aβ across the BBB and examined the contribution of apoE to this process.

Abstract
Alzheimer’s disease (AD) is a neurodegenerative process characterized, in part, by the accumulation of beta-amyloid proteins (Aβ) in the brain. Evidence now suggests the excessive Aβ accumulation is the result of impaired clearance from the brain. Recent studies have indicated that retinoid X receptor (RXR) activation stimulates the metabolic clearance of Aβ and rapidly reverses Aβ-induced behavioral deficits, doing so in an apoE-dependent manner. Previously we reported that soluble apoE (i.e., not bound to Aβ) facilitated Aβ transit across the BBB. As Aβ clearance from the brain involves both metabolic and BBB-mediated processes, the current studies investigated the impact of RXR stimulation on Aβ clearance across the BBB. Treatment with RXR agonists increased Aβ clearance across the BBB both in vitro and in vivo. Moreover, this processes appeared to involve apoE as RXR agonism did not stimulate Aβ BBB clearance when apoE was absent. Thus, RXR activation could mitigate Aβ brain burden by promoting both the metabolic and BBB clearance of Aβ, offering a novel approach to the treatment of AD.

August 7, 2012

Event: Journal Club “Traumatic axonal injury in the optic nerve: evidence for axonal swelling, disconnection, dieback, and reorganization.”

We will be presenting the paper on Friday (7/20/2012) at 4:00 PM in Roskamp Institute. Title: Traumatic axonal injury in the optic nerve: evidence for axonal swelling, disconnection, dieback, and reorganization.

Wang J, Hamm RJ, Povlishock JT. Traumatic axonal injury in the optic nerve: evidence for axonal swelling, disconnection, dieback, and reorganization. J Neurotrauma. 2011 Jul;28(7):1185-98. Epub 2011 Jul 12.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

August 2, 2012

Event: Journal Club ” A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline.”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 1:04 pm

We will be presenting the paper on Friday (7/20/2012) at 4:00 PM in Roskamp Institute. Title: A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline.

Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jönsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K. A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature. 2012 Jul 11. doi: 10.1038/nature11283. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

July 9, 2012

Journal club

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 12:48 pm

Event: Journal Club ” Identification and Validation of Target Pathways Influencing Outcome After Traumatic Brain Injury.”

One of our PhD students has submitted his final thesis which he will be presenting at this week’s Journal Club. The title is “Identification and Validation of Target Pathways Influencing Outcome After Traumatic Brain Injury.”

We hope you can join us at the Roskamp Institute at 4pm this Friday.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

June 19, 2012

Event: Journal Club ” Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.”.

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 1:06 pm

We will be presenting the paper on Friday (6/22/2012) at 4:00 PM in Roskamp Institute. Title:  ” Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.”.
Dual modification of Alzheimer’s disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach. Acta Neuropathologica Volume 123, Number 1 (2012), 105-117, DOI: 10.1007.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

June 4, 2012

Event: Journal Club ” Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells “.

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 12:53 pm

We will be presenting the paper on Friday (6/8/2012) at 4:00 PM in Roskamp Institute. Title:  ” Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells “.

Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS. Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells. Nature. 2012 Feb 9;482(7384):216-20.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

May 14, 2012

Event: Journal Club “Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease “.

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 3:04 pm

Alex Bishop will be presenting the paper on Friday (5/18/2012) at 4:00 PM in Roskamp Institute. Title:  “Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease “.
Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H. Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, and Kun Ping Lu, Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease, Cell, 149(1), March 2012, Pages 232-244
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

May 8, 2012

A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier

Filed under: Uncategorized — Tags: — Gogce Crynen @ 12:39 pm

Dr. Bachmeier and Dr. Crawford recently published an article in Neurodegenerative Diseases titled “A multifaceted role for apoE in the clearance of beta-amyloid across the blood-brain barrier”. This report clarifies the role of apoE in the exchange of Aβ across the BBB and describes the contribution of apoE to Aβ accumulation in the AD brain.

Abstract
Background: While apolipoprotein E4 (apoE4) is highly correlated with the development of Alzheimer’s disease (AD), its role in AD pathology and, in particular, beta-amyloid (Aβ) removal from the brain, is not clearly defined. Objective: To elucidate the influence of apoE on the clearance of Aβ across the BBB. Methods: Aβ(1-42) was intracerebrally administered to transgenic mice expressing human apoE isoforms and examined in the periphery. Results: ApoE3 and apoE4 mice had 5-times and 2-times, respectively, more Aβ(1-42) appearing in the plasma than wild-type or apoE knockout mice, indicating an enhanced clearance of Aβ from the brain to the periphery. In vitro, unbound basolateral apoE3 (i.e., not bound to Aβ), and to a lesser extent unbound apoE4, at concentrations ≤10nM facilitated basolateral-to-apical fluorescein-Aβ(1-42) transcytosis across a blood-brain barrier (BBB) model, while apoE isoforms bound to Aβ significantly disrupted Aβ transcytosis. Additionally, following apical exposure to the BBB model, we found apoE4 bound to Aβ is able to penetrate the BBB more readily than apoE3 bound to Aβ and does so via the RAGE transporter. Conclusion: These studies indicate a multifaceted, isoform-dependent role for apoE in the exchange of Aβ across the BBB and may partially explain the association of apoE4 and Aβ brain accumulation in AD.

May 7, 2012

Event: Journal Club ” Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury “.

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 5:31 pm

Benoit Mouzon will be presenting the paper on Friday (5/11/2012) at 4:00 PM in Roskamp Institute. Title:  ” Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury “.
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

Tang-Schomer MD, Johnson VE, Baas PW, Stewart W, Smith DH. Partial interruption of axonal transport due to microtubule breakage accounts for the formation of periodic varicosities after traumatic axonal injury. Exp Neurol. 2012 Jan;233(1):364-72. Epub 2011 Nov 4. PMID: 22079153

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

May 1, 2012

Event: Journal Club “Trans-cellular propagation of Tau aggregation by fibrillar species “.

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:29 pm

Robert Pellot will be presenting the paper on Friday (5/4/2012) at 4:00 PM in Roskamp Institute. Title:  ” Trans-cellular propagation of Tau aggregation by fibrillar species “.
Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI ;Trans-cellular propagation of Tau aggregation by fibrillar species ; Journal of Biological Chemistry ; 29 March, 2012. Epub Ahead of Print.
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

April 23, 2012

Event: Journal Club “Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid”.

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 12:46 pm

Scott Ferguson will be presenting the paper on Friday (4/27/2012) at 4:00 PM in Roskamp Institute. Title:  “Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid”.
Manda, K., Ueno, M. and Anzai, K., 2008. Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid. Behav Brain Res. 187, 387-395.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

April 13, 2012

Roskamp Institute Researcher to Discuss Traumatic Brain Injuries With Player, Filmmaker After April 19 Screening


SARASOTA, FL – As the National Football League takes steps to reduce concussions and other traumatic brain injuries (TBIs), a new film being premiered at the Sarasota Film Festival tells the tragic personal story of NFL star Kevin Turner.  After an eight-year career with the New England Patriots and Philadelphia Eagles, Kevin Turner now suffers from amyotrophic lateral sclerosis (ALS), a fatal nervous system condition also known as Lou Gehrig’s disease.

“Kevin is a gentle but broken man of 42, a football superstar forced to reflect on the price he is paying for his glory years,” said filmmaker Jon Frankel in advance of the April 19 world premier of his movie “American Man” at the Opera House. “In the decade since he retired, Kevin lost his job, his money, his marriage and even, he thinks, his mind.”
Following the April 19 premiere, Dr. Fiona Crawford, associate director of The Roskamp Institute, will join Turner and Frankel for a panel discussion of the latest research into the long-term impact of multiple head injuries.  “We have been modeling repetitive head injury in our Sarasota laboratory, and found there is a significant difference in terms of behavior and pathology compared with a single injury,” said Crawford, whose findings were presented at a recent meeting of the International Brain Injury Association in Scotland. “There are cognitive deficits with the repetitive injury, but no obvious deficits after 12 months with a single injury,” said Crawford.

Frankel, a correspondent for HBO-REAL Sports, shot the film about Turner’s life from August 2010 to fall 2011.  “He has lost considerable use of his hands and arms but still drives,” he said. “The disease has not hit his legs yet. He is beginning to have a little more trouble talking.  But he still sounds pretty darn good since being diagnosed two years ago.”

Turner was drafted by the Patriots as a fullback in 1992, joined Philadelphia three years later and ended his playing career in 1999. He believes the multiple concussions and head injuries from football led to the onset of ALS.  Turner is believed to be the 14th former NFL player diagnosed with ALS since 1960, a rate twice as likely than someone not suffering from repeated concussions.

In recent years, the NFL has tightened its rules regarding helmet-to-helmet “hits” and how quickly a player can return to the game after suffering a concussion. The spring, the NFL severely disciplined the New Orleans Saints for running a bounty system that rewarded team members who injured opposing players.

# # #

For tickets to the AMERICAN MAN film premiere:

http://sarasota.festivalgenius.com/2012/films/americanman_jonfrankel_sarasota2012

Date: Thursday, April 19, 2012

Where:  Sarasota Opera House

Time: VIP Reception to Benefit The Roskamp Institute begins 6pm

Screening at 7:30pm, Panel discussion immediately follows

The Roskamp Institute is a scientific research facility devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders.  The Institute utilizes a broad range of scientific approaches to understanding the causes of – and potential therapies for – these disorders with an emphasis on Alzheimer’s disease.

The Institute is located in Sarasota, Florida where it operates a memory clinic.

April 11, 2012

Event: Journal Club ” Concussive brain injury enhances fear learning and excitatory processes in the amygdala “.

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 2:22 pm

Ariel Gonzalez will be presenting the paper on Friday (4/13/2012) at 4:00 PM in Roskamp Institute. Title:  ” Concussive brain injury enhances fear learning and excitatory processes in the amygdala “.
Reger ML, Poulos AM, Buen F, Giza CC, Hovda DA, Fanselow MS.Concussive brain injury enhances fear learning and excitatory processes in the amygdala. Biol Psychiatry. 2012 Feb 15;71(4):335-43.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

April 2, 2012

Event: Journal Club ” Lipidomics profiling of brain and plasma tissue from mice exposed to Gulf War agents “.

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 2:19 pm

Laila Abdullah and she  will be presenting  data entitled, “Lipidomics profiling of brain and plasma tissue from mice exposed to Gulf War agents” on Friday (3/30/2012) at 4:00 PM in Roskamp Institute

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 26, 2012

Event: Journal Club ” Regulatory T cells suppress sickness behaviour development without altering liver injury in cholestatic mice “, ” Liver-induced inflammation hurts the brain”.

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 12:50 pm

Zuchra Zakirova will be presenting the paper on Friday (3/30/2012) at 4:00 PM in Roskamp Institute. Title:  ” Regulatory T cells suppress sickness behaviour development without altering liver injury in cholestatic mice “, ” Liver-induced inflammation hurts the brain”.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

Kimchi Nguyen, Charlotte D’Mello, Tai Le, Stefan Urbanski, Mark G. Swain, Regulatory T cells suppress sickness behaviour development without altering liver injury in cholestatic mice, Journal of Hepatology, Volume 56, Issue 3, March 2012, Pages 626-631, ISSN 0168-8278, 10.1016/j.jhep.2011.09.014.

(http://www.sciencedirect.com/science/article/pii/S0168827811007768)

Rita Garcia-Martinez, Juan Cordoba, Liver-induced inflammation hurts the brain, Journal of Hepatology, Volume 56, Issue 3, March 2012, Pages 515-517, ISSN 0168-8278, 10.1016/j.jhep.2011.11.003.

(http://www.sciencedirect.com/science/article/pii/S0168827811008026)

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 15, 2012

Event: Journal Club ” Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition “

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 12:45 pm

Chris Mayer will be presenting the paper on Friday (3/16/2012) at 4:00 PM in Roskamp Institute. Title:  ” Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition”

Condello C.,  Schain A., Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. 2011. Scientific Reports 1, Article number: 19 doi:10.1038/srep00019

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 9, 2012

NILVAD

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 12:15 pm

To learn about NILVAD project partners and for more information on NILVAD please follow the link:

http://www.alzheimer-europe.org/News/Alzheimer-Europe/Wednesday-15-February-2012-NILVAD-project-team-holds-first-meeting-in-Dublin

March 8, 2012

Event: Journal Club ” The dynamic structure of filamentous tau “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:20 pm

Robert Pelot will be presenting the paper on Friday (3/10/2012) at 4:00 PM in Roskamp Institute.
Title:  ” The dynamic structure of filamentous tau ”

Bibow S, Mukrasch MD, Chinnathambi S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. The dynamic structure of filamentous tau. Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4. doi: 10.1002/anie.201105493. Epub 2011 Oct 11.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 27, 2012

Event: Journal Club ” Diffusion Tensor Imaging Detects Axonal Injury in a Mouse Model of Repetitive Closed-Skull Traumatic Brain Injury “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 4:32 pm

Scott Ferguson will be presenting the paper on Friday (3/2/2012) at 4:00 PM in Roskamp Institute.
Title:  ” Diffusion Tensor Imaging Detects Axonal Injury in a Mouse Model of Repetitive Closed-Skull Traumatic Brain Injury ”

Bennett, R. E., Donald, C. L. and Brody, D. L., Diffusion Tensor Imaging Detects Axonal Injury in a Mouse Model of Repetitive Closed-Skull Traumatic Brain Injury. Neurosci Lett.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 23, 2012

Event: Journal Club ” Trans-synaptic spread of tau pathology in vivo. “

Filed under: Uncategorized — Tags: — Gogce Crynen @ 12:37 pm

Myles Mullan will be presenting the paper on Friday (2/24/2012) at 4:00 PM in Roskamp Institute.

Title:  ” Trans-synaptic spread of tau pathology in vivo ”
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K. Trans-synaptic spread of tau pathology in vivo. PLoS One. 2012;7(2):e31302

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 14, 2012

News:KEY CLINICAL TRIAL OF ALZHEIMER’S DISEASE DRUG BEGINS IN EUROPE DRUG DISCOVERED BY ROSKAMP INSTITUTE RESEARCH

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 12:46 pm
Contact: Steve Klindt
Tel: Tel:941-752-2949 x 390
Email: Sklindt@roskampinstitute.net

KEY CLINICAL TRIAL OF ALZHEIMER’S DISEASE DRUG BEGINS IN EUROPE DRUG DISCOVERED BY ROSKAMP INSTITUTE RESEARCH
SARASOTA, FL (Feb. 14) –

A research team today announced the launch of a European large-scale clinical trial of Nilvadipine, an Alzheimer’s disease drug developed at the Roskamp Institute (www.rfdn.org) in Sarasota. More than 500 Alzheimer’s patients in nine European countries will participate in the phase III trial designed to study the effectiveness of the medication.

“We believe that Nilvadipine blocks the production of amyloid proteins linked to Alzheimer’s disease,” said Roskamp Institute President and CEO Michael Mullan, M.D., Ph.D., who along with Associate Director Fiona Crawford, Ph.D., and Daniel Paris Ph.D. led the team that developed the drug. “That means Nilvadipine is aimed at addressing the actual disease, and not just the symptoms.”

A consortium of medical teams from nine European countries is meeting in Ireland this week to plan the US$10 million multicenter study. Phase III studies are usually the last step in the regulatory process before a drug can move into clinical practice. The consortium, called NILVAD for Nilvadipine/Alzheimer’s Disease, will involve participants from Ireland, England, Hungary, Greece, France, Sweden, Germany, Italy and the Netherlands.

The 500 participants, who have mild to moderate cognitive impairments, will begin the double-blind study this fall. Each participant will be followed for 18 months to see if the drug produces a change in cognitive abilities.

“We won’t cure Alzheimer’ disease without clinical trials,” said Crawford, who added that major pharmaceutical companies have not been able to come up with an effective drug. “Currently, there are only eight interventions underway in phase III trial, and it’s a tremendous achievement for a small research institute like ours to be part of the process.”

Event: Journal Club ” Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats. “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:43 pm

Zuchra Zakirova will be presenting the paper on Friday (2/17/2012) at 4:00 PM in Roskamp Institute.
Title:  “Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats ”

Truettner J.S., Alonso O.F., Bramlett H.M., Dietrich W.D. “Therapeutic hypothermia alters microRNA responses to traumatic brain injury in rats”. J Cereb Blood Flow Metab. 2011 Sep;31(9):1897-907

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 7, 2012

Event: Journal Club ” Lipidomic profiling of brain phosphatidylcholines and sphingomyelins in mice with motor and anxiety-like features of GWI ”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:46 pm

We will have a special presentation for Journal Club this Friday (2/10/2012) at 4pm at the Roskamp Institute. Instead of reviewing a journal article, this week’s presenter — Laila Abdullah — will be presenting results from her own research. The title of her presentation is “Lipidomic profiling of brain phosphatidylcholines and sphingomyelins in mice with motor and anxiety-like features of GWI.”
Title: ” Lipidomic profiling of brain phosphatidylcholines and sphingomyelins in mice with motor and anxiety-like features of GWI.”

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 30, 2012

Event: Journal Club ” Alzheimer’s disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. ”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 2:03 pm

Benoit Mouzon will be presenting the paper on Friday (2/3/2012) at 4:00 PM in Roskamp Institute.
Title: “ Alzheimer’s disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging.”

Maarouf CL, Daugs ID, Kokjohn TA, Walker DG, Hunter JM, Kruchowsky JC, Woltjer R, Kaye J, Castaño EM, Sabbagh MN, Beach TG, Roher AE. Alzheimer’s disease and non-demented high pathology control nonagenarians: comparing and contrasting the biochemistry of cognitively successful aging. PLoS One. 2011;6(11):e27291. Epub 2011 Nov 7.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.
The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 23, 2012

Event: Journal Club ” Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 1:11 pm

Alex Bishop will be presenting the paper on Friday (1/13/2012) at 4:00 PM in Roskamp Institute.
Title: ” Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons ”

Liang Qiang, Ryousuke Fujita, Toru Yamashita, Sergio Angulo, Herve Rhinn, David Rhee, Claudia Doege, Lily Chau, Laetitia Aubry, William B. Vanti et al. 2011. Directed Conversion of Alzheimer’s Disease Patient Skin Fibroblasts into Functional Neurons. Cell. 146(3) pp. 359 – 371.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 11, 2012

Event: Journal Club ” Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer’s NFTs ”

Robert Pelot will be presenting the paper on Friday (1/13/2012) at 4:00 PM in Roskamp Institute.

Title: ” Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer’s NFTs ”

Rudrabhatla P, Jaffe H, Pant HC. Direct evidence of phosphorylated neuronal intermediate filament proteins in neurofibrillary tangles (NFTs): phosphoproteomics of Alzheimer’s NFTs. FASEB J. 2011 Nov;25(11):3896-905. Epub 2011 Aug 9.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 5, 2012

Event: Journal Club ” Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer’s disease ”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:38 pm

Laila Abdullah will be presenting the paper on Friday (1/6/2012) at 4:30 PM in Roskamp Institute.

Title: “Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer’s disease ”

Wood PL, Smith T, Lane N, Khan MA, Ehrmantraut G, Goodenowe DB. Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer’s disease. Lipids Health Dis. 2011 Dec 5;10(1):227. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

December 6, 2011

Special guest speaker

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:46 pm
Dr. Cathy Walsh, PhD
Manager and Senior Scientist, Marine Immunology Program,
Mote Marine Laboratory

will present:

Pathways of Programmed Cell Death in Tumor Cells Exposed
to Shark Immune Cell-Derived Peptides

Friday, December 9, 2011 at 3:30 pm
 in the Roskamp Institute Auditorium 

This is the first in a symposium series where scientists from the Mote Marine Laboratory and the Roskamp Institute will meet to discuss recent scientific work 
being conducted at each respective research facility.

November 28, 2011

Event: Journal Club ” Protective effect of e-viniferin on b-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:03 pm

Robert Pelot will be presenting the paper on Friday (12/02/2011) at 4:00 PM in Roskamp Institute.

Title: ” Protective effect of e-viniferin on b-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry ”

Protective effect of e-viniferin on b-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry.Tristan Richard , Pascal Poupard, Merian Nassra, Yorgos Papastamoulis, Marie-Laure Iglésias, Stéphanie Krisa, Pierre Waffo-Teguo, Jean-Michel Mérillon, Jean-Pierre Monti. Bioorganic & Medicinal Chemistry 19 (2011) 3152–3155

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

November 9, 2011

Event: Journal Club ” Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 2:00 pm


Scott Ferguson will be presenting the paper on Friday (11/11/2011) at 4:00 PM in Roskamp Institute.

Title: ” Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor ”

Ressler, K. J., Mercer, K. B., Bradley, B., Jovanovic, T., Mahan, A., Kerley, K., Norrholm, S. D., Kilaru, V., Smith, A. K., Myers, A. J., Ramirez, M., Engel, A., Hammack, S. E., Toufexis, D., Braas, K. M., Binder, E. B. and May, V., Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature. 470, 492-497.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

State College of Florida’s A.S. Biotechnology program on November 8, 2011.

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:57 pm

The Roskamp Institute’s Dr Ghania Ait-Ghezala and James Humphrey are guest speakers for the State College of Florida’s A.S. Biotechnology program on November 8, 2011. Dr Ait-Ghezala and Mr. Humphrey will be talking on Genetic Testing and the Ethics of Genetic Testing.  The Roskamp Institute strongly supports education in the sciences. The Roskamp Institute is a not-for-profit organization and Dr Mike Mullan is CEO of the Roskamp Institute.

November 1, 2011

Event: Journal Club “Single particle analysis of tau oligomer formation induced by metal ions and organic solvents “

Filed under: Uncategorized — Tags: — Gogce Crynen @ 12:25 pm

Benoit Mouzon will be presenting the paper on Friday (11/04/2011) at 4:00 PM in Roskamp Institute.

Title: ” Single particle analysis of tau oligomer formation induced by metal ions and organic solvents ”

Single particle analysis of tau oligomer formation induced by metal ions and organic solvents. Bader B, Nübling G, Mehle A, Nobile S, Kretzschmar H, Giese A. Biochem Biophys Res Commun. 2011 Jul 22;411(1):190-6. Epub 2011 Jun 24.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

October 27, 2011

Event: Journal Club ” Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 9:32 am

Robert Pelot will be presenting the paper on Friday (10/28/2011) at 4:00 PM in Roskamp Institute.

Title: ” Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis”

Diane P. Hanger, Helen L. Byers, Selina Wray, Kit-Yi Leung, Malcolm J. Saxton, Anjan Seereeram, C. Hugh Reynolds, Malcolm A. Ward, and Brian H. Anderton. Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis, J. Biol. Chem., Vol. 282, Issue 32, 23645-23654, August 10, 2007.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

October 10, 2011

Event: Journal Club Early TBI-Induced Cytokine Alterations are Similarly Detected by Two Distinct Methods of Multiplex Assay “

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 5:20 pm


Scott Ferguson will be presenting the paper on Friday (10/14/2011) at 4:00 PM in Roskamp Institute.

Title: “Early TBI-Induced Cytokine Alterations are Similarly Detected by Two Distinct Methods of Multiplex Assay ”

Mukherjee, S., Katki, K., Arisi, G. M., Foresti, M. L. and Shapiro, L. A., Early TBI-Induced Cytokine Alterations are Similarly Detected by Two Distinct Methods of Multiplex Assay. Front Mol Neurosci. 4, 21.Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

October 3, 2011

Event: Journal Club ” Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:05 pm

Alex Bishop will be presenting the paper on Friday (10/07/2011) at 4:00 PM in Roskamp Institute.

Title: ” Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation ”

Markus P. Kummer, Michael Hermes, Andrea Delekarte, Thea Hammerschmidt, Sathish Kumar, Dick Terwel, Jochen Walter, Hans-Christian Pape, Simone König, Sigrun Roeber, Frank Jessen, Thomas Klockgether, Martin Korte, Michael T. Heneka, Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation, Neuron, Volume 71, Issue 5, 8 September 2011, Pages 833-844, ISSN 0896-6273, 10.1016/j.neuron.2011.07.001.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 28, 2011

Event: Journal Club ” The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats ” and ” Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 10:10 pm

Benoit Mouzon will be presenting the paper on Friday (9/30/2011) at 4:00 PM in Roskamp Institute.

Title: ” The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats ” and ” Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor”

The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats. Zhao J, Li G, Zhang Y, Su X, Hang C. Cytokine. 2011 Aug 13.

Erythropoietin improves histological and functional outcomes after traumatic brain injury in mice in the absence of the neural erythropoietin receptor. Xiong Y, Mahmood A, Qu C, Kazmi H, Zhang ZG, Noguchi CT, Schallert T, Chopp M. J Neurotrauma. 2010 Jan;27(1):205-15.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 8, 2011

Event: Journal Club ” A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 2:30 pm

Chris Kline will be presenting the paper on Friday (9/9/2011) at 4:00 PM in Roskamp Institute.

Title: ” A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain.”

Puram SV, Kim AH, Ikeuchi Y, Wilson-Grady JT, Merdes A, Gygi SP, Bonni A. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Nat Neurosci. 2011 Jul 3;14(8):973-83.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 30, 2011

Event: Journal Club “Stress and traumatic brain injury: a behavioral, proteomics, and histological study “

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 9:51 am

Scott Ferguson will be presenting the paper on Friday (9/2/2011) at 4:00 PM in Roskamp Institute.

Title: ” Stress and traumatic brain injury: a behavioral, proteomics, and histological study.”

Kwon, S. K., Kovesdi, E., Gyorgy, A. B., Wingo, D., Kamnaksh, A., Walker, J., Long, J. B. and Agoston, D. V.,2011. Stress and traumatic brain injury: a behavioral, proteomics, and histological study. Front Neurol. 2, 12.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 15, 2011

Event: Journal Club ” Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer’s disease models.”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:44 am

Laila Abdullah will be presenting the paper on Friday (8/19/2011) at 4:00 PM in Roskamp Institute.

Title: ” Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer’s disease models.”

Zhao Y, Calon F, Julien C, Winkler JW, Petasis NA, Lukiw WJ, Bazan NG. Docosahexaenoic acid-derived neuroprotectin D1 induces neuronal survival via secretase- and PPARγ-mediated mechanisms in Alzheimer’s disease models. PLoS One. 2011 Jan 5;6(1):e15816.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 2, 2011

Event: Journal Club ” The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 10:45 am

Benoit Mouzon will be presenting the paper on Friday (8/5/2011) at 4:00 PM in Roskamp Institute.

Title: ” The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.”

Corrigan F, Pham CL, Vink R, Blumbergs PC, Masters CL, van den Heuvel C, Cappai R. The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains.Brain Res. 2011 Mar 10;1378:137-43. Epub 2011 Jan 6.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

July 26, 2011

Event: Journal Club ” Nicotinic acetylcholine receptor signalling: roles in Alzheimer’s disease and amyloid neuroprotection.” and ” Alpha7 neuronal nicotinic receptors: the missing link to understanding Alzheimer’s etiopathology?”

John Phillips will be presenting the paper on Friday (7/29/2011) at 4:00 PM in Roskamp Institute.

Title: ” Nicotinic acetylcholine receptor signalling: roles in Alzheimer’s disease and amyloid

neuroprotection.” and ” Alpha7 neuronal nicotinic receptors: the missing link to understanding Alzheimer’s etiopathology?”

Buckingham SD, Jones AK, Brown LA, Sattelle DB. Nicotinic acetylcholine

receptor signalling: roles in Alzheimer’s disease and amyloid

neuroprotection. Pharmacol Rev. 2009 Mar;61(1):39-61. Epub 2009 Mar 16.

Bencherif M, Lippiello PM. Alpha7 neuronal nicotinic receptors: the missing

link to understanding Alzheimer’s etiopathology? Med Hypotheses. 2010

Feb;74(2):281-5. Epub 2009 Oct 1.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

July 19, 2011

Event: Journal Club ” Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury “

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 9:24 am

Scott Ferguson will be presenting the paper on Friday (7/22/2011) at 4:00 PM in Roskamp Institute.


Title: ” Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury ”

Garman RH, Jenkins LW, Switzer RC, Bauman RA, Tong LC, Swauger PV, Parks SA, Ritzel DV, Dixon CE, Clark RS, Bayır H, Kagan V, Jackson EK, Kochanek PM.Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury. 2011 J Neurotrauma. Jun;28(6):947-59.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

July 13, 2011

Event: Journal Club ” Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration.”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 9:57 am

Alex Bishop will be presenting the paper on Friday (7/15/2011) at 4:00 PM in Roskamp Institute.

Title: ” Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration ”

Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, Giorgini F, Moussaoui S, Laue G, Rassoulpour A, Flik G, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. 2011. Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration. Cell 145, 863–874

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

July 5, 2011

Event: Journal Club “Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid.”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 11:28 am

Laila Abdullah will be presenting the paper on Friday (7/8/2011) at 4:00 PM in Roskamp Institute.

Title: ” Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid ”

He C, Qu X, Cui L, Wang J, Kang JX. Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid. Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11370-5

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

June 20, 2011

Event: Journal Club ” Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function.”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 1:24 pm

Benoit Mouzon will be presenting the paper on Friday (6/24/2011) at 4:00 PM in Roskamp Institute.


Title: ” Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function ”

Creed JA, DiLeonardi AM, Fox DP, Tessler AR, Raghupathi R. Concussive brain trauma in the mouse results in acute cognitive deficits and sustained impairment of axonal function. J Neurotrauma. 2011 Apr;28(4):547-63.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

June 13, 2011

Event: Journal Club” Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation. “

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 4:10 pm

Scott Ferguson will be presenting the paper on Friday (6/17/2011) at 4:00 PM in Roskamp Institute.

Title: Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation.

Luh C, Gierth K, Timaru-Kast R, Engelhard K, Werner C, Thal SC. Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation. PLoS One. 2011;6(5):e19948. Epub 2011 May 19.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

May 31, 2011

Event: Journal Club” Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats “

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 1:32 pm

Laila Abdullah will be presenting the paper on Friday (6/3/2011) at 4:00 PM in Roskamp Institute.


Title: Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats

Lee B, Sur BJ, Han JJ, Shim I, Her S, Lee HJ, Hahm DH. Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1085-93.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

May 25, 2011

ALZHEIMER’S DISEASE DRUG DEVELOPED AT ROSKAMP INSTITUTE APPROVED FOR KEY CLINICAL TRIAL FUNDING IN EUROPE

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:08 am

ALZHEIMER’S DISEASE DRUG DEVELOPED AT ROSKAMP INSTITUTE

APPROVED FOR KEY CLINICAL TRIAL FUNDING IN EUROPE

SARASOTA, FL – An international research consortium led by Trinity College Dublin (Ireland) today announced the selection for funding of a large-scale European clinical trial of Nilvadipine, an Alzheimer’s disease drug developed at the Roskamp Institute in Sarasota. More than 500 Alzheimer’s patients will participate in the multicenter Phase III clinical trial designed to study the effectiveness of Nilvadipine.

“We need many more medicines to move forward into advanced clinical trials in the fight against Alzheimer’s Disease and we are pleased the Roskamp Institute has played such a major role in the development of this drug,” said Michael Mullan, M.D., Ph.D., Roskamp Institute director who, with associate director Fiona Crawford, Ph.D. and lead scientist Daniel Paris, Ph.D., led the research team that developed the drug.  Phase III studies are usually the last step in the regulatory process before a drug can move into clinical practice.

“Only a handful of Alzheimer’s drugs have ever reached this stage, and most were developed by major pharmaceutical companies.  It’s a tremendous achievement for a research institute like ours to be part of the process,” said Crawford.

Brian Lawlor, M.D., Connolly Norman Professor of Old Age Psychiatry at Trinity College Dublin, Ireland, will be principal investigator and coordinator of the US$ 8.4 million Nilvadipine study, which is being funded by the European Commission Seventh Framework Programme.  More than 20 European clinical sites will participate in the placebo-controlled study.  Anticipated to begin in early 2012, patients with mild to moderate Alzheimer’s disease will be recruited to participate.

“Considering the devastating impact that Alzheimer’s disease has on people, there is relatively little research funding being made available to tackle this major killer,” said Lawlor.

The clinical trials will take place in Europe, where Nilvadipine is already approved for use in mild cases of hypertension (high blood pressure). “The process can move more quickly in Europe, and the study findings may help accelerate the process with the U.S. Food and Drug Administration (FDA),” Mullan said.

Mullan and Crawford have been studying Alzheimer’s disease for more than 20 years, moving from the UK to Florida in 1991 and to Sarasota in 2003 to establish the Roskamp Institute.  “Some of our recent studies have involved Sarasota area residents, who have contributed to our understanding of Alzheimer’s disease and helped move the development process forward,” said Crawford.

In the Sarasota laboratories, the research team discovered that Nilvadipine, a drug approved in Europe for treatment of hypertension, can stop the accumulation of the amyloid proteins in the brain – a development that has been implicated in Alzheimer’s disease. A combined Phase I/II clinical trial was completed in Europe by the Institute last year and focused on Nilvadipine’s safety. “The initial results indicated that patients with Alzheimer’s disease were able to tolerate the drug well,”   said Mullan.

Now, the Roskamp Institute will provide research support for the Phase III clinical trial, such as assessing genetic and other markers for Alzheimer’s disease in study participants.

The Institute’s commercial spinoff, Archer Pharmaceuticals, owns the intellectual property rights to Nilvadipine, and Mullan serves as Archer’s chief executive officer.  “There are always risks involved with drug development and discovery,” said Mullan. “But we must continue to invest in new approaches in the worldwide battle against Alzheimer’s disease.”

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. The Institute is located in Sarasota, Florida, and operates a memory clinic onsite.

For more information:  www.rfdn.org

Contact:  Steve Klindt

Tel: 941-752-2949

Email: sklindt@roskampinstitute.org

May 24, 2011

Event: Journal Club ” Inflammation modulates anxiety in an animal model of multiple sclerosis”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 11:51 am

Helena Chaytow will be presenting the paper on Friday (5/27/2011) at 4:00 PM in Roskamp Institute.

Title: Inflammation modulates anxiety in an animal model of multiple sclerosis

Isabella Peruga, Silvia Hartwig, Jan Thöne, Bernhard Hovemann, Ralf Gold, Georg Juckel and Ralf A. Linker.Behavioural Brain Research, 20 June 2011, Volume 220, Issue 1, Pages 20-29

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

May 16, 2011

May 9, 2011

Event: Journal Club “Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 10:08 am

Alex Bishop will be presenting the paper on Friday (5/13/2011) at 4:00 PM in Roskamp Institute.

Title: “Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan ”

Nature 472, 226–229 (14 April 2011) doi:10.1038/nature09873

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

May 3, 2011

Event: Journal Club ” Neuronal activity regulates the regional vulnerability to amyloid-β deposition.”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 11:25 am

John Phillips will be presenting the paper on Friday (5/6/2011) at 4:00 PM in Roskamp Institute.

Title: ” Neuronal activity regulates the regional vulnerability to amyloid-β deposition ”

Nature Neuroscience Published online: 01 May 2011 | doi:10.1038/nn.2801

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

April 18, 2011

Event: Journal Club ” Repeated, intermittent exposures to diisopropylfluorophosphate in rats: protracted effects on cholinergic markers, nerve growth factor-related proteins, and cognitive function.”

Filed under: Uncategorized — Gogce Crynen @ 10:58 am

Laila Abdullah will be presenting the paper on Friday (4/22/2011) at 4:00 PM in Roskamp Institute.

Title: ” Repeated, intermittent exposures to diisopropylfluorophosphate in rats: protracted effects on cholinergic markers, nerve growth factor-related proteins, and cognitive function ”

Neuroscience. 2011 Mar 10;176:237-53. Epub 2010 Dec 24.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

April 15, 2011

VA Research Day, at James A. Haley Veterans’ Hospital, on April 14th 2011

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 9:55 am

Roskamp Institute scientist and Open University PhD students presented posters during VA Research Day, at James A. Haley Veterans’ Hospital, on April 14th 2011. You can find the abstracts of these poster below.

Proteomic-based identification of a CNS biological profile of delayed cognitive impairment in mice exposed to Gulf War agents.

Laila Abdullah,* Alex Bishop,* John Phillips, Scott Ferguson,*†‡ Benoit Mouzon,*†‡*‡ Jon Reed,*† Gogce Crynen,*‡ Myles Mullan,*† Venkat Mathura,* Michael Mullan,*†

Ghania Ait-Ghezala,*†‡ and Fiona Crawford*†‡

*Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243

†James A. Haley VA Hospital, 13000 Bruce B. Downs Blvd, Tampa, FL, 33612

‡The Open University, Walton Hall, Milton Keynes, MK7 6AA

Background: Gulf War Illness (GWI) is a chronic multisymptom condition with a central nervous system (CNS) component, for which there is no treatment currently available.  It is now believed that the combined exposure to Gulf War (GW) agents, including pyridostigmine bromide (PB) and pesticides, such as permethrin (PER), was a key contributor to the etiology of GWI.  Aim: In this study, a proteomic approach was used to characterize the biomolecular disturbances that accompany neurobehavioral and neuropathological changes associated with combined exposure to PB and PER.  Method: Wild-type CD1 mice were exposed to 2mg/kg PB and 200 mg/kg of PER via i.p. in DMSO daily for 10 days and the control group received DMSO only.  Following exposure, neurobehavioral profile were examined using the Rotarod test to assess motor deficits, the Open Field test for anxiety-related changes and the Morris Water Maze test to assess spatial memory.  Mice were subsequently euthanized for proteomic and histopathological studies.  Results: Mice exposed to PB and PER over 10 days showed an increase in anxiety-like behavior and delayed cognitive impairment compared to control mice that received vehicle only.  Hence, GW agent exposed mice recapitulate the chronic and delayed emergence of the cognitive impairment associated with GWI.  Comparative proteomic approaches showed changes in proteins associated with lipid metabolism and molecular transport in the brains of GW agent exposed mice compared to controls.  Proteins associated with the endocrine and the immune systems were also altered, and dysfunction of these systems is a prominent feature of GWI.  The presence of astrogliosis in the GW agent exposed mice compared to control mice further suggests an immune system imbalance, as is observed in GWI.  Conclusion: These studies provide a broad perspective of the molecular disturbances driving the late pathology of this complex illness.  Evaluation of the potential role of these biological functions in GWI will be useful in identifying molecular pathways to target for development of novel therapeutics for the treatment of GWI.

Funding:

This work is supported by a Congressionally Directed Medical Research Program award to Dr. Fiona Crawford (Grant#: GW080094).

Behavioral outcome in a mouse model of single and multiple concussions

Benoit Mouzon*†, Helena Chaytow*, Corbin Bachmeier*, Michael Mullan*†, and Fiona Crawford*†
*Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243

†James A. Haley VA Hospital, 13000 Bruce B. Downs Blvd, Tampa, FL, 33612

Abstract:

Concussion or mild traumatic brain injury(mTBI), is the most common type of TBI. The World Health Organization (WHO) estimated that between 70 and 90% of head injuries that receive treatment are mild. Despite its prevalence, mTBI has only recently become accepted as a major health issue since the intense media attention brought to the public on the high incidence of TBI in military conflicts and on high-profile professional athletes. In the United States, every year, more than 2 million people sustain a TBI, principally as a result of falls (35.2%), motor vehicle accidents (17.3%), violence, sports-related injuries and nearby explosions on the battlefield.  An understanding of the cellular mechanisms succeeding TBI is important as this is a major public health problem in industrialized countries.

The purpose of this study is to develop and characterize a novel mTBI model in rodents that replicates the pathological components or phases of human clinical mTBI. This model has several advantages over currently available rodent models of TBI like controlled cortical impact, weight drop, or the fluid percussion model. One advantage of this model is that the location of the hit on the midline allows the whole brain to be used for analyses.  This new model is also of particular interest to investigate military or sports related concussions, where the soldier/athletes usually receive multiple hits over a relatively short period of their lifetime. Repetitive mTBI is believed to be associated with at least two devastating complications.  An increase in brain vulnerability to a second concussive impact and/or 2) chronic cognitive impairments, such as chronic traumatic encephalopathy (CTE), which are often associated with accelerated neurodegeneration in specific brain regions.  These  data validate our model of mild head injury and demonstrate a temporal window of vulnerability to repetitive head trauma that results in behavioral dysfunction.

APP is Internalized After CD40 Ligation Which Increases Aβ Production

Ghania Ait-Ghezala1,2, Ekta Shah1, Jeremy Frieling1, Helena Chaytow1, Claude-Henry Volmar3,and Michael J. Mullan1,2

1Roskamp Institute, Sarasota, FL 34243.  2James A. Haley Veterans’ Hospital, Tampa, FL 33612.  3Scripps Research Institute, Jupiter, FL 33458.

ABSTRACT

CD40, a member of the tumor necrosis factor receptor superfamily, and its cognate ligand CD40L both have elevated levels in the brains of Alzheimer’s disease (AD) patients compared to controls. We have shown that pharmacological or genetic interruption of CD40/CD40L interaction results in mitigation of AD-like pathology in vivo in transgenic AD mouse models, and in vitro. Previously we showed that CD40L stimulation induces Ab production potentially through the g-secretase. Particularly we report an increase in levels of Ab (1-40) and Ab (1-42). We have also recently shown that CD40 ligation triggers internalization of APP, and that internalization by endocytosis is associated with increased Ab production. To further test whether lipid raft translocation of APP is indeed triggered by CD40 ligation, we have expressed a CD40/CD45 chimera in vitro. We will ultimately use this chimera to measure the impact of ligation on Ab production.

CD40 Ligand Deficiency Improves Rate of Functional Recovery Following Traumatic Brain Injury

Scott Ferguson1,2, Benoit Mouzon1,2, John Phillips1, Gogce Kayihan1,2, Helena Chaytow1, Alex Bishop1, Laila Abdullah1, Myles Mullan1, Venkatarajan Mathura1,2, Michael Mullan1,2, Fiona Crawford1,2

1Roskamp Institute, 2040 Whitfield Ave, Sarasota, FL, 34243

2James A. Haley VA Hospital, 13000 Bruce B. Downs Blvd, Tampa, FL, 33612

Abstract

Traumatic brain injury (TBI) has been diagnosed in 178,876 service members from 2000 to the first quarter of 2010. The neurobehavioral sequelae of TBI persist long after the injury, which consists of both a primary insult to the brain as well as secondary injury that occurs in the hours and days immediately thereafter.  In order to find targets for therapeutic intervention we have analyzed the proteomic profile of the response to injury by Apolipoprotein E (APOE) transgenic mice.  Polymorphisms in APOE are known to impact the outcome after TBI, with the APOE4 allele (and concomitant ApoE4 expressed protein) associated with worse outcome than ApoE3 following TBI.

Proteomic analysis of the response to injury by APOE transgenic mice revealed multiple pathways differentially regulated in APOE3 and APOE4 mice following injury, suggesting a potential role of those pathways in modulating the outcome from injury.  One of these pathways involved CD40-related molecules.  CD40 and its ligand, CD154, have been shown to be upregulated in patients following cerebral ischemia (Garlichs et al, 2003). A study by Ishikawa et al (2005) also showed CD40 and CD40 ligand deficient mice have reduced infarct volume in a mouse model of ischemia, and given that ischemic conditions are known to occur in the brain following TBI, we used CD40 ligand (CD40L) knockout mice (Jackson Laboratories) to study the effect of CD40 signaling in a CCI model of severe TBI.

Rotarod testing was used to evaluate neuromotor skills and the Barnes maze was employed to test spatial learning and memory.  Our results showed that CD40L knockout mice showed an improved rate of functional recovery following TBI compared to wild type controls, as well as improved performance on both the Rotarod and Barnes maze tasks overall.

April 11, 2011

News: James Humphrey will talk at Suncoast workforce Bi-County Healthcare Commitee

Filed under: Uncategorized — Gogce Crynen @ 5:14 pm

COO of Roskamp Institute, Mr James Humphrey will talk at Bi-County Healthcare Committee meeting organized by Suncoast workforce. The meeting will be held on Wednesday , April 13, 2011, 8 AM at 3660 N. Washington Blvd. Sarasota FL 34234.

Event: Journal Club ” Psychosis in Alzheimer’s Disease in the National Alzheimer’s Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E ” and ” Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier model “

Filed under: Uncategorized — Tags: , , , , , , , — Gogce Crynen @ 2:13 pm

Ekta Shah will be presenting the paper on Friday (4/15/2011) at 4:00 PM in Roskamp Institute.

Title: ” Psychosis in Alzheimer’s Disease in the National Alzheimer’s Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E ” and ” Apolipoprotein E regulates the integrity of tight junctions in an isoform-dependent manner in an in vitro blood-brain-barrier model ”

International Journal of Alzheimer’s Disease, Volume 2011 (2011), Article ID 926597, 8 pages

doi:10.4061/2011/926597 and  JBC, 2011, doi: 10.1074/jbc.M111.225532 , respectively.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

April 4, 2011

Event: Journal Club ” Mechanical Tissue Resuscitation Treatment Reduces Brain Tissue Volume and Intracerebral Hemorrhage and Increases Blood Perfusion in a Traumatic Brain Injury Model in Swine” and “Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 5:27 pm

Benoit Mouzon will be presenting the paper on Friday (4/08/2011) at 4:00 PM in Roskamp Institute.

Title: ” Mechanical Tissue Resuscitation Treatment Reduces Brain Tissue Volume and Intracerebral Hemorrhage and Increases Blood Perfusion in a Traumatic Brain Injury Model in Swine” and “Efficacy and mechanisms of vacuum-assisted closure (VAC) therapy in promoting wound healing: a rodent model”

2010, Conference paper, http://handle.dtic.mil/100.2/ADA532538 and J Plast Reconstr Aesthet Surg. 2009 Oct;62(10):1331-8. Epub 2008 Jul 9, respectively.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 29, 2011

Event: Journal Club “Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 10:03 am

Helena Chaytow will be presenting the paper on Friday (4/1/2011) at 4:00 PM in Roskamp Institute.

Title: Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice

Nature(2011) doi:10.1038/nature09822

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 23, 2011

Event: Journal Club “Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:35 am

Scott Ferguson will be presenting the paper on Friday (3/25/2011) at 4:00 PM in Roskamp Institute.

Title: Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

ASN Neuro. 2011 Feb 16;3(1):e00051.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 14, 2011

Event: Journal Club “Reversing EphB2 depletion rescues cognitive functions in Alzheimer model”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 2:24 pm

John Phillips will be presenting the paper on Friday (3/18/2011) at 4:00 PM in Roskamp Institute.

Title: Reversing EphB2 depletion rescues cognitive functions in Alzheimer model

6 JANUARY 201 1 | VOL 469 | NATURE | 47

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 7, 2011

Event: Journal Club “High ability of apolipoprotein E4 to stabilize amyloid-peptide oligomers, the pathological entities responsible for Alzheimer’s disease”

Filed under: Uncategorized — Tags: , , , , , — Gogce Crynen @ 11:27 am

Laila Abdullah will be presenting the paper on Friday (3/4/2011) at 4:00 PM in Roskamp Institute.


Title: High ability of apolipoprotein E4 to stabilize amyloid-peptide oligomers, the pathological entities responsible for Alzheimer’s disease

FASEB J. 2011 Jan 25. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 3, 2011

Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:13 am

February 14, 2011

Dr. Corbin Bachmeier of the Roskamp Institute and Dr. Gary Levin of the University of Southern Nevada recently published an article in Biopharmaceutics and Drug Disposition titled “Induction of drug efflux protein expression by venlafaxine but not desvenlafaxine”.  They observed that venlafaxine induced drug efflux protein expression in cell culture, whereas its metabolite, desvenlafaxine, had no impact on drug efflux protein levels.  They are currently exploring this phenomenon further in an in vivo paradigm through a grant provided by Pfizer.

Abstract

Venlafaxine and its metabolite desvenlafaxine are serotonin-norepinephrine reuptake inhibitors currently prescribed for the treatment of depression.  Previously, we reported venlafaxine is an inducer of MDR1, the gene responsible for P-glycoprotein (P-gp).  In the present study, we expanded upon these findings by examining the effect of venlafaxine and desvenlafaxine on the expression of both P-gp and the breast cancer resistance protein (BCRP) in human brain endothelial cells (HBMEC), an in vitro model of the blood-brain barrier (BBB).  The HBMEC were treated for 1 hour with various concentrations (500nM to 50µM) of venlafaxine and desvenlafaxine.  Western blot analysis revealed treatment with venlafaxine significantly induced the expression of P-gp (2-fold) and BCRP (1.75-fold) in a dose-dependent manner, while treatment with desvenlafaxine had no effect on drug efflux transporter expression.  To determine the functional significance of this effect, we examined the permeability of a known drug efflux probe, rhodamine 123, across the BBB model and Caco-2 cells, a model of intestinal absorption.  Treatment with venlafaxine (1µM to 50µM) for 1 hour significantly reduced the apical-to-basolateral permeability of R123 across the BBB model (30%) and Caco-2 cell monolayers (25%), indicative of increased drug efflux transporter expression at the apical membrane.  Conversely, desvenlafaxine had no effect on R123 permeability in either cellular model.  These studies indicate that venlafaxine, but not desvenlafaxine is an inducer of drug efflux transporter expression, which consequently increases the potential for clinical drug-drug interactions.  Therefore, based on these preliminary results, caution should be taken when prescribing venlafaxine with other P-gp substrates.

February 28, 2011

Event: Journal Club “Identification of Candidate IgG Biomarkers for Alzheimer’s Disease via Combinatorial Library Screening”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 3:07 pm

Alex Bishop will be presenting the paper on Friday (3/4/2011) at 4:00 PM in Roskamp Institute.

Title: Identification of Candidate IgG Biomarkers for Alzheimer’s Disease via Combinatorial Library Screening

Cell 144, 132–142, January 7, 2011

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

News: Dr Crawford is presenting the Roskamp Institute Gulf War Illness Research Program

Filed under: news — Tags: , — Gogce Crynen @ 10:36 am
Dr Fiona Crawford is presenting the Roskamp Institute Gulf War Illness Research Program
to the Research Advisory Committee on Gulf War Veterans’ Illnesses in Washington, DC
today. Although there has been surprisingly little media coverage, it is the 20th anniversary of the 1991 conflict.  Dr
Crawford together with other experts and veterans suffering from Gulf War Illness are discussing what is now known about this chronic
multi-symptom illness, and how basic and clinical research programs such as the one at Roskamp are advancing toward effective treatment for this devastating
disease.

February 25, 2011

Epitope-dependent effects of beta-amyloid antibodies on beta-amyloid clearance in an in vitro model of the blood-brain barrier

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 11:03 am

February 14, 2011

Dr. Bachmeier and Dr. Paris recently published an article in Microcirculation titled “Epitope-dependent effects of beta-amyloid antibodies on beta-amyloid clearance in an in vitro model of the blood-brain barrier”.  This report offers an explanation as to why some antibody-based immunotherapies are more effective than others in lowering brain amyloid levels in AD.

Abstract

Objective: To investigate the role of the receptor for advanced glycation end products (RAGE) in the epitope-dependent effects of beta-amyloid (Aβ) antibodies used as a peripheral sink therapy in Alzheimer’s disease.

Methods: An in vitro model of the blood-brain barrier (BBB) was used to examine the effect of various Aβ antibodies or Aβ peptide fragments on Aβ exchange across the BBB.

Results: An N-terminal Aβ antibody significantly enhanced the basolateral-to-apical transcytosis of fluorescein-Aβ(1-42) across the BBB model (41%), while no effect was apparent with a C-terminal Aβ antibody.  Interestingly, modulation of RAGE in the presence of a C-terminal Aβ antibody resulted in a 65% increase in Aβ clearance of across the BBB model, suggesting the C-terminal antibody-Aβ complex is susceptible to RAGE transport.  Additionally, N-terminal peptide fragments of Aβ attenuated the brain penetration of full length Aβ in the BBB model, indicating the N-terminal region of Aβ is required for brain uptake.

Conclusions: Antibodies masking the N-terminal region of Aβ increase Aβ clearance across the BBB by preventing Aβ from interacting with the RAGE transporter, whereas antibodies bound to the C-terminus of Aβ are taken up by RAGE and, hence, do not influence the BBB clearance of Aβ.

February 21, 2011

Event: Journal Club “Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 11:15 am

Benoit Mouzon will be presenting the paper on Friday (2/25/2011) at 4:00 PM in Roskamp Institute.

Title: Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching

Off the Toxic Tau Mutant.

The Journal of Neuroscience, February 16, 2011 • 31(7):2511–2525 • 2511

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 17, 2011

A grant from Pfizer to study the effect of two antidepressant medications for Roskamp Institute Scientist

1-13-2011

Dr. Corbin Bachmeier of the Roskamp Institute in collaboration with Dr. Gary Levin of the University of Southern Nevada recently received a grant from Pfizer to study the effect of two antidepressant medications currently on the market, venlafaxine (Effexor) and desvenlafaxine (Pristiq), on the expression of the drug efflux transport proteins P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) in vivo.  This work is a continuation of their previous efforts, supported through a grant from Wyeth Pharmaceuticals, which determined that venlafaxine induces drug efflux protein expression in brain endothelial cells, an in vitro model of the blood-brain barrier (BBB), in a dose dependant manner.  Moreover, these effects were functionally significant as treatment with venlafaxine reduced the permeability of a known drug efflux probe, rhodamine 123, across the BBB model and Caco-2 cell monolayers, a model of intestinal absorption.  Conversely, treatment with desvenlafaxine in the BBB model did not result in a statistically significant change in the expression of either P-gp or BCRP nor did desvenlafaxine impact the permeability of R123 across the BBB model or Caco-2 monolayers.  As it is difficult to predict clinical outcomes based solely on in vitro observations, the current in vivo studies will examine the impact of these compounds on drug efflux protein expression in a live animal.  In doing so, these studies will provide a better understanding of the potential for drug-drug interactions and the relevance of these effects to a clinical setting.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 7, 2011

Event: Journal Club “Neurogenesis in Adult Human Brain after Traumatic Brain Injury. ”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 3:39 pm

Scott Ferguson will be presenting the paper on Friday (2/11/2011) at 4:00 PM in Roskamp Institute.

Title: Neurogenesis in Adult Human Brain after Traumatic Brain Injury.

J Neurotrauma. 2011 Jan 30. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 1, 2011

Event: Journal Club “Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer’s disease. ”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 10:09 am

Ekta Shah will be presenting the paper on Friday (2/4/2011) at 4:00 PM in Roskamp Institute.

Title: Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer’s disease.

J Biol Chem. 2010 Nov 30. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 24, 2011

Event: Journal Club “Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis “

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:21 pm

Laila Abdullah will be presenting the paper on Friday (1/28/2011) at 4:00 PM in Roskamp Institute.

Title: Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

PNAS July 6, 2010 vol. 107 no. 27 12233-12238

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 17, 2011

Event: Journal Club “The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer’s disease and related tauopathies”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 10:15 am

Chris Mayer will be presenting the paper on Friday (1/21/2011) at 4:00 PM in Roskamp Institute.

Title: The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer’s disease and related tauopathies

Pharmacol Res. 2010 Dec 14. [Epub ahead of print]

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

January 11, 2011

One Pill. Once A Day. A clinical trial for those with Relapsing-Remitting Multiple Sclerosis.

Filed under: Clinical Trials — Tags: , , — Gogce Crynen @ 1:33 pm

Patients Like Me Trial Awareness V1

Ono-RRMS-U006

One Pill.  Once A Day.  A clinical trial for those with Relapsing-Remitting Multiple Sclerosis.

Imagine MS treatment without the injections.  Without the subsequent pain, bruising and burning.  Doctors specializing in MS treatment are currently researching alternatives that could make treatment a whole lot easier to take.

About the DreaMS research study

The DreaMS clinical trial is evaluating the effectiveness and safety of an oral investigational medication (taken by mouth) for RRMS.  Researchers are also interested in learning if the investigational medication has fewer side effects and is a less-invasive alternative to the injectable RRMS medications currently available.

The study is evaluating 3 different doses of the study medication to inactive placebo.  Study participants have a 3 in 4 (75%) chance of receiving the investigational medication versus inactive placebo.

To qualify for the study you must:

  • Be 18-55 years of age
  • Have a medical diagnosis of relapsing-remitting MS
  • Have had your first MS symptoms within the past 12 years

The study staff will determine your full eligibility.  If you take part, all study-related care is provided at no cost to you including study visits, physical exams, diagnostic tests, and study medication/placebo.  Compensation is also provided if you take part.

To learn more and find out if you pre-qualify for the DreaMS study, please visit www.DreamsClinicalTrial.com.

January 4, 2011

Event: Journal Club “Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 1:56 pm


Helena Chaytow will be presenting the paper on Friday (1/7/2011) at 4:00 PM in Roskamp Institute.

Title: Synergistic benefits of erythropoietin and simvastatin after traumatic brain injury

Brain Res. 2010 Nov 11;1360:177-92. Epub 2010 Sep 15.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

December 22, 2010

Selective antihypertensive dihydropyridines lower Aβ accumulation by targeting both the production and the clearance of Aβ across the blood-brain barrier

Abstract

Several large population based or clinical trial studies have suggested that certain dihydropyridine (DHP) L-type calcium channel blockers (CCBs) used for the treatment of hypertension may confer protection against the development of Alzheimer’s disease (AD). However, other studies with drugs of the same class have shown no beneficial clinical effects. In order to determine whether certain DHPs are able to impact underlying disease processes in AD (specifically the accumulation of the Alzheimer’s Aβ peptide), we investigated the effect of several antihypertensive DHPs and non-DHP CCBs on Aβ production. Among the antihypertensive DHPs tested, a few, including nilvadipine, nitrendipine and amlodipine inhibited Aβ production in vitro whereas others had no effect or raised Aβ levels. In vivo, nilvadipine and nitrendipine acutely reduced brain Aβ levels in a transgenic mouse model of AD (Tg PS1/APPsw) and improved Aβ clearance across the blood-brain barrier (BBB) whereas amlodipine and nifedipine were ineffective showing that the Aβ lowering activity of the DHPs is independent of their antihypertensive activity. Chronic oral treatment with nilvadipine decreased Aβ burden in the brains of Tg APPsw (Tg2576) and Tg PS1/APPsw mice and also improved learning abilities and spatial memory. Our data suggest that the clinical benefit conferred by certain antihypertensive DHPs against AD is unrelated to their antihypertensive activity but rely on their ability to lower brain Aβ accumulation by affecting both Aβ production and Aβ clearance across the BBB.

Paris DBachmeier CPatel NQuadros AVolmar CHLaporte VGaney JBeaulieu-Abdelahad DAit-Ghezala GCrawford FMullan MJ.

Mol Med. 2010 Dec 17. [Epub ahead of print]

Characterization and Use of Human Brain Microvascular Endothelial Cells to Examine β-amyloid Exchange in the Blood-Brain Barrier

Dr. Bachmeier and Dr. Paris recently published an article in Cytotechnology entitled “Characterization and Use of Human Brain Microvascular Endothelial Cells to Examine β-amyloid Exchange in the Blood-Brain Barrier”. They are currently using this model of the BBB to elucidate the mechanisms responsible for the removal of β-amyloid from the brain. In addition, this model is being used as a screen to identify molecules that facilitate β-amyloid clearance across the BBB with the goal of discovering a new class of therapies for the treatment of Alzheimer’s disease.

Abstract Alzheimer’s disease (AD) is characterized by excessive cerebrovascular deposition of the β-amyloid peptide (Aβ). The investigation of Aβ transport across the blood-brain barrier (BBB) has been hindered by inherent limitations in the cellular systems currently used to model the BBB, such as insufficient barrier properties and poor reproducibility. In addition, many of the existing models are not of human or brain origin and are often arduous to establish and maintain. Thus, we characterized an in vitro model of the BBB employing human brain microvascular endothelial cells (HBMEC) and evaluated its utility to investigate Aβ exchange at the blood-brain interface. Our HBMEC model offers an ease of culture compared with primary isolated or coculture BBB models and is more representative of the human brain endothelium than many of the cell lines currently used to study the BBB. In our studies, the HBMEC model exhibited barrier properties comparable to existing BBB models as evidenced by the restricted permeability of a known paracellular marker. In addition, using a simple and rapid fluormetric assay, we showed that antagonism of key Aβ transport proteins significantly altered the bi-directional transcytosis of fluorescein-Aβ (1-42) across the HBMEC model. Moreover, the magnitude of these effects was consistent with reports in the literature using the same ligands in existing in vitro models of the BBB. These studies establish the HBMEC as a representative in vitro model of the BBB and offer a rapid fluorometric method of assessing Aβ exchange between the periphery and the brain.

December 7, 2010

Event: Journal Club “A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 4:04 pm


Scott Ferguson will be presenting the paper on Friday (12/10/2010) at 4:00 PM in Roskamp Institute.

Title: A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus

www.sciencexpress.org / 2 December 2010 / Page 1 / 10.1126/science.1197258

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

November 16, 2010

Event: Journal Club, Neuroscience San Diego 2010 meeting highlights

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:51 am
Please join us at 4:00 pm this Friday at the Roskamp Institute for Journal Club. We will have a special presentation by Laila Abdullah, Scott Ferguson, and Benoit Mouzon of the highlights of the 2010 Society for Neuroscience conference.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

November 11, 2010

Event: Journal Club “Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications”

Filed under: Uncategorized — Tags: — Gogce Crynen @ 11:32 am

Benoit Mouzon will be presenting the paper on Friday (11/12/2010) at 4:00 PM in Roskamp Institute.

Title: Biochemical and neurochemical sequelae following mild traumatic brain injury: summary of experimental data and clinical implications

Neurosurg Focus 29 (5):E1, 2010

Journal Club is held every Friday. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

November 3, 2010

Wednesday, November 10, 2010

Filed under: Uncategorized — Gogce Crynen @ 5:32 pm

The Tri-Chamber Business After Hours Expo will be held at the Sarasota-Manatee Convention Center where over 1400 members/guests from Sarasota, Manatee, and Venice Area Chambers will converge to network and view each other’s products and services.  The Roskamp Institute will show representation at their Sponsored Booth.

The Roskamp Institute Memory Clinic and Clinical Trials Division provide a full range of services for individuals with Alzheimer’s disease including diagnostic work-up and follow-up treatment, neuropsychological examination, clinical trial opportunities, and memory screening.  For more information, please call (941) 256-8018.

November 3 – 5, 2010

Filed under: Clinical Trials — Tags: — Gogce Crynen @ 5:30 pm

Roskamp Institute Clinical Research Coordinators and Principal Investigator of the Clinical Trials Division will be attending an Investigator’s Meeting for a new Relapsing Remitting Multiple Sclerosis study that they will soon be enrolling eligible candidates in to.

The Roskamp Institute Memory Clinic and Clinical Trials Division provide a full range of services for individuals with Alzheimer’s disease including diagnostic work-up and follow-up treatment, neuropsychological examination, clinical trial opportunities, and memory screening.  For more information, please call (941) 256-8018.

Event: Journal Club “Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 5:24 pm

John Phillips will be presenting the paper on Friday (11/05/2010) at 4:30 PM in Roskamp Institute.

Title: Gamma-secretase activating protein is a therapeutic target for Alzheimer’s disease.

Vol 467| 2 September 2010| doi:10.1038/nature09325

Journal Club is held every Friday. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

October 4, 2010

Event: Journal Club “ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:48 pm

Laila Abdullah will be presenting the paper on Friday (10/08/2010) at 4:30 PM in Roskamp Institute.

Title: ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.

PNAS | June 29, 2010 | vol. 107 | no. 26 | 12011–12016

Journal Club is held every Friday. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 28, 2010

Event: Journal Club “Morphologic and Biochemical Characterization of Brain Injury in a Model of Controlled Blast Overpressure Exposure”

Filed under: Uncategorized — Gogce Crynen @ 12:55 pm

Benoit Mouzon will be presenting the paper on Friday (10/01/2010) at Roskamp Institute.

Title: Morphologic and Biochemical Characterization of Brain Injury in a

Model of Controlled Blast Overpressure Exposure.

The Journal of TRAUMA,2010 Mar 2. [Epub ahead of print]

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 22, 2010

Event: Journal Club “Amyloid-beta-42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 9:37 am
Laila Abdullah will be presenting the paper on Friday (9/24/2010) at Roskamp Institute.

Title:  Amyloid-beta-42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

PNAS, December 8, 2009, vol. 106, no. 49, 20936–20941

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 13, 2010

Title: Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis,on processing of the beta-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 10:32 am

Nowell (Jim) Ganey will be presenting the paper on Friday (9/17/2010) at Roskamp Institute.

Title:  Effect of VEGF and its receptor antagonist SU-5416, an inhibitor of angiogenesis,on processing of the beta-amyloid precursor protein in primary neuronal cells derived from brain tissue of Tg2576 mice.

Int J Dev Neurosci. 2010 Jul 22. [Epub ahead of print] doi:10.1016/j.ijdevneu.2010.07.231

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

News:Scientific team at the Roskamp Institute found evidence to support that processes controlling the growth of cerebral blood vessels are altered in the brains of transgenic mouse models of Alzheimer’s disease

Sarasota, Florida). Scientists at the Roskamp Institute in Sarasota, in collaboration with researchers from the H. Lee Moffitt Cancer Center in Tampa, have found laboratory evidence that the processes controlling the growth of cerebral blood vessels are altered  in the brains of transgenic mouse models of Alzheimer’s disease (AD). Scientists say the discovery will provide a better understanding of the role of cerebrovascular lesions in AD brains and may explain why vascular insults synergistically precipitate the cognitive presentation of AD. In addition, their research may provide new therapeutical approaches which are desperately needed to tackle this devastating disorder. AD is the most common form of dementia among the aging population and is characterized by the intracerebral accumulation of a small protein called b-amyloid, as well as, neurofibrillary tangles that form in the neurons of the affected patients. In addition to neuronal damages, AD brains also present evidence of capillary degeneration and a reduction in brain capillary density which probably contribute to the decreased cerebral blood flow reported in all patients suffering from the disease. The growth of blood vessels (or angiogenesis) is controlled by the balance between several growth factors that can stimulate their growth and other molecules that inhibit their formation. The amount of growth factors that normally stimulate angiogenesis is elevated in AD brains, which could suggest that the growth of cerebrovessels would be stimulated in AD. The growth of tumors is dictated by their vascularization, this is particularly true for brain tumors which are highly vascularized. Therefore, in order to determine whether angiogenesis was possibly altered in AD brains, the researchers implanted brain tumors in transgenic mouse models of AD (that have been genetically engineered to reproduce some of the AD brain pathology) as well as normal mice and measured the growth of the tumors in the animals. “Interestingly, we observed that the growth and vascularization of brain tumors was reduced in transgenic mouse models of AD compared to normal mice, suggesting that the AD brain does not constitute a favorable environment to support the growth of new blood vessels.” said Dr. Daniel Paris of the Roskamp Institute, lead author of the study published in the Journal of Neuroscience (J. Neurosci. 2010;30(34):11251-8). “Our data suggest the growth of new brain capillaries that takes place following a stroke for example, and allows for a restoration of the cerebral blood flow in the damage area, will be inhibited in AD. This may explain why vascular insults such as stroke are known to accelerate the cognitive decline in AD patients. Overall, our work suggests that therapies stimulating brain vascularization may be beneficial in AD patients.”, Dr. Paris added. Epidemiological studies have highlighted that the incidence of cancer is reduced in AD patients whereas the prevalence of AD is reduced in patients with an history of cancer suggesting a biological link between cancer and AD. “As the growth of blood vessels is required for the development of tumors, our work suggesting some impairment in the growth of blood vessels in AD may provide a biological mechanism explaining this intriguing relationship between cancer and AD.”, Dr. Paris said. The Roskamp Institute is a not-for-profit research Institute located in Sarasota, Fla., that is dedicated to understanding the causes of, and finding cures for, neuropsychiatric and neurodegenerative disorders with an emphasis on Alzheimer’s disease. The Institute’s Memory Clinic also offers comprehensive cognitive and medical assessment toward differential diagnosis of Alzheimer’s disease and offers treatments and disease management options once the diagnostic evaluation is complete. For more information, please contact the Institute at (941) 752-2949, Roskamp’s Clinical Trials Division in Sarasota at (941) 256-8018 or visit www.RoskampInstitute.com.

News: Roskamp Institute on myFOX Tampa bay

Filed under: Uncategorized — Gogce Crynen @ 9:45 am

myFOX Tampa Bay broad-casted a section on Roskamp Institute, to watch it online please follow the link.

September 8, 2010

Event: Journal Club “Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury”

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 9:50 am

Scott Ferguson will be presenting the paper on Friday (9/10/2010) at Roskamp Institute.


Title:  Gp91phox (NOX2) in classically activated microglia exacerbates traumatic brain injury.

Journal of Neuroinflammation 2010, 7:41      doi:10.1186/1742-2094-7-41

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 2, 2010

Event: Journal Club “Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer’s disease compared to cognitively intact control subjects”


Alex Bishop will be presenting the paper on Friday (9/3/2010) at Roskamp Institute.

Title:  “Allopregnanolone levels are reduced in temporal cortex in patients with Alzheimer’s disease compared to cognitively intact control subjects”

Biochimica et Biophysica Acta 1801 (2010) 951–959

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 23, 2010

Event: Journal Club “Is there a gender difference in mortality after TBI?”

Filed under: TBI — Tags: , — Gogce Crynen @ 1:16 pm

Benoit Mouzon will be presenting the following papers on Friday (8/27/2010) at Roskamp Institute.

Title:  Severe traumatic brain injury: is there a gender difference in mortality?

The American Journal of Surgery (2009) 197, 155–158.

And

Title: The Effect of Gender on Patients With Moderate to Severe Head Injuries

The Journal of Trauma 2009 Nov; 67 (5), 950-953.

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 18, 2010

Event: Journal Club “AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 10:59 am

Nowell (Jim) Ganey will be presenting the paper on Friday (8/20/2010) at Roskamp Institute.

Title: AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

Journal: Neurobiology of Aging.

2010 Jul 16. [Epub ahead of print]  doi:10.1016/j.neurobiolaging.2010.05.026

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 12, 2010

News:Business Partners in Education 20th Annual Business /Education Partnership Awards

The Manatee Chamber of Commerce and the School Board of Manatee County  presented the 20th Annual Business Partners in Education Awards on Thursday, August 12th at Freedom Village. Due to our partnership with Southeast High School, Roskamp Institute was nominated several categories including “Special One-Time project”. Although we did not get the award this year, Manatee Chamber of Commence presented Roskamp Institute a certificate that states “In recognition of your commitment to the student of manatee County and for your dedication as an outstanding partner for the 2009-2010 school year”.

We are hoping to be involved in new Business/ Education partnership projects in coming years.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 9, 2010

Event: Journal Club “ CD40/CD40 Ligand Signaling in Mouse Cerebral Microvasculature After Focal Ischemia/Reperfusion”

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 10:37 am

Scott Ferguson will be presenting the paper on Friday (8/13/2010) at Roskamp Institute.

Title:  CD40/CD40 Ligand Signaling in Mouse Cerebral Microvasculature After Focal Ischemia/Reperfusion

Journal: Circulation.

2005;111:1690-1696.

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

August 6, 2010

Governor Charlie Crist visits Roskamp Institute

Filed under: news — Tags: , , , — Gogce Crynen @ 1:28 pm

Governor Charlie Crist visited our Institute on Thursday, and was briefed about the most recent scientific breakthroughs that have occurred at the Institute, followed by a full tour of the laboratories.  Impressed with what he saw, Gov. Crist referred to the Institute as “Florida’s best-kept scientific secret.”

Alzheimer’s disease is a growing epidemic in Florida, and the Governor and Senatorial candidate was receptive to concerns raised by Institute scientists regarding future funding opportunities for Alzheimer’s research. There is currently no State funding for Alzheimer’s research in Florida, despite this state being one of the hardest hit by this devastating disease.  When such funds once more become available it is hoped that they will be distributed using a peer-review process (as used for State funding of Cancer research) so that the tax payers receive most “bang for their buck” with the best research programs receiving the funding.

The visit underscores the growing prominence of the Roskamp Institute within the Sarasota/Manatee community and greater local recognition for the Institute’s nationally and internationally recognized contributions to research progress in Alzheimer’s Disease, Cancer and other disorders. Gov. Crist also discussed the Institute’s research programs that are of critical importance to the military and veterans populations – Traumatic Brain Injury, Post Traumatic Stress Disorder and Gulf War Illness.  He was also interested in the innovative Ph.D. program now flourishing at Roskamp, as well as the Institute’s for-profit spin off, Archer Pharmaceuticals.

Gov. Crist’s visit was the most recent in a series of high-profile visits to the Institute, which have included visits from Senator Bill Nelson and Congressman C. W. Bill Young.  James Humphrey, Roskamp COO was encouraged by the visit, as it was yet another means by which the the Institute can “reach out into the public domain” and raise awareness of the scope of research being conducted in the Sarasota/Manatee area

August 4, 2010

Roskamp Institute in the news

Filed under: news — Tags: — Gogce Crynen @ 10:22 am

Our chief operating officer James Humprey attended Manatee County Commissioners’ “We’re Listening” Session.

For details please visit Bradenton Times web site or Bradenton.com

July 19, 2010

Event: Journal Club “Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations”

Filed under: alzheimer — Tags: , , , , , — Gogce Crynen @ 4:17 pm


John Phillips will be presenting the paper on Friday (7/30/2010) at Roskamp Institute.

Title: Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

Journal: Cell

Volume 141, Issue 7, 1146-1158, 10 June 2010

Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

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