Roskamp Institute Articles Better Science. Real Discovery.

May 14, 2012

Event: Journal Club “Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease “.

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 3:04 pm

Alex Bishop will be presenting the paper on Friday (5/18/2012) at 4:00 PM in Roskamp Institute. Title:  “Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease “.
Kazuhiro Nakamura, Alex Greenwood, Lester Binder, Eileen H. Bigio, Sarah Denial, Linda Nicholson, Xiao Zhen Zhou, and Kun Ping Lu, Proline Isomer-Specific Antibodies Reveal the Early Pathogenic Tau Conformation in Alzheimer’s Disease, Cell, 149(1), March 2012, Pages 232-244
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

May 1, 2012

Event: Journal Club “Trans-cellular propagation of Tau aggregation by fibrillar species “.

Filed under: Uncategorized — Tags: , — Gogce Crynen @ 1:29 pm

Robert Pellot will be presenting the paper on Friday (5/4/2012) at 4:00 PM in Roskamp Institute. Title:  ” Trans-cellular propagation of Tau aggregation by fibrillar species “.
Kfoury N, Holmes BB, Jiang H, Holtzman DM, Diamond MI ;Trans-cellular propagation of Tau aggregation by fibrillar species ; Journal of Biological Chemistry ; 29 March, 2012. Epub Ahead of Print.
Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949.

March 8, 2012

Event: Journal Club ” The dynamic structure of filamentous tau “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 12:20 pm

Robert Pelot will be presenting the paper on Friday (3/10/2012) at 4:00 PM in Roskamp Institute.
Title:  ” The dynamic structure of filamentous tau ”

Bibow S, Mukrasch MD, Chinnathambi S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M. The dynamic structure of filamentous tau. Angew Chem Int Ed Engl. 2011 Nov 25;50(48):11520-4. doi: 10.1002/anie.201105493. Epub 2011 Oct 11.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

October 27, 2011

Event: Journal Club ” Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis “

Filed under: Uncategorized — Tags: , , — Gogce Crynen @ 9:32 am

Robert Pelot will be presenting the paper on Friday (10/28/2011) at 4:00 PM in Roskamp Institute.

Title: ” Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis”

Diane P. Hanger, Helen L. Byers, Selina Wray, Kit-Yi Leung, Malcolm J. Saxton, Anjan Seereeram, C. Hugh Reynolds, Malcolm A. Ward, and Brian H. Anderton. Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis, J. Biol. Chem., Vol. 282, Issue 32, 23645-23654, August 10, 2007.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

March 23, 2011

Event: Journal Club “Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 10:35 am

Scott Ferguson will be presenting the paper on Friday (3/25/2011) at 4:00 PM in Roskamp Institute.

Title: Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

ASN Neuro. 2011 Feb 16;3(1):e00051.

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

February 21, 2011

Event: Journal Club “Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant”

Filed under: Uncategorized — Tags: , , , — Gogce Crynen @ 11:15 am

Benoit Mouzon will be presenting the paper on Friday (2/25/2011) at 4:00 PM in Roskamp Institute.

Title: Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching

Off the Toxic Tau Mutant.

The Journal of Neuroscience, February 16, 2011 • 31(7):2511–2525 • 2511

Journal Club is held every Friday. For change in schedule please check our Twitter account or Facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

September 22, 2010

Event: Journal Club “Amyloid-beta-42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism”

Filed under: Uncategorized — Tags: , , , , — Gogce Crynen @ 9:37 am
Laila Abdullah will be presenting the paper on Friday (9/24/2010) at Roskamp Institute.

Title:  Amyloid-beta-42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism.

PNAS, December 8, 2009, vol. 106, no. 49, 20936–20941

Journal Club is held every Friday between 4 pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

June 8, 2010

Event Journal Club:Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice

Amyloid-β and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer’s disease mice by Rhein et al.

Alex Bishop will be presenting the paper on Friday (6/11/2010) at Roskamp Institute.

Journal Club is held every Friday between 4 Pm-5pm. For change in schedule please check our twitter account or facebook page.

The Roskamp Institute is devoted to understanding causes and finding cures for neuropsychiatric and neurodegenerative disorders and addictions. The Institute utilizes a broad range of scientific approaches to understanding the causes of and potential therapies for these disorders with an emphasis on Alzheimer’s disease. For more information, please call (941)752-2949

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